Scientist (Tumor Immunology and Organoid Models)

About This Role

A*STAR is seeking a highly motivated Research Fellow in Tumor Immunology and Organoid Models to lead research on tumor-immune interactions, organoid model development/validation, and therapeutic target discovery.

Responsibilities

• Lead independent research projects in tumor-immune cell interactions and inflammatory signaling.
• Design, execute, and oversee mechanistic studies using molecular and immunological approaches for organoid models.
• Perform in vivo experiments using syngeneic and orthotopic mouse tumor models to validate findings.
• Analyze multi-omics and immunological datasets, including spatial transcriptomics.
• Contribute to manuscript preparation, grant writing, and mentorship of junior researchers.
• Ensure good organization and documentation of all experimental procedures and data.

Requirements

• Ph.D. in Cancer Biology, Molecular Biology, Biochemistry, Immunology or related discipline.
• Demonstrated track record of leading research projects independently and first authored publications in high-quality peer-reviewed journals.
• Prior experience in leading cancer immunology projects and generation of organoid models is highly advantageous.
• Strong expertise in mammalian cell culture, lentivirus production and transduction, FACS, immunohistochemistry.
• Proficient in the characterization of mouse tumor models and organoid culture systems.
• Experience with spatial transcriptomics and computational analysis of transcriptomic datasets is highly desirable.
• Strong proficiency in scientific writing, presentation of research findings, and organizational skills.