About the role
The Scientist/Senior Scientist, RNA Analytical Development will lead the creation and execution of phase‑appropriate analytical strategies for RNA‑based raw materials, drug substances and drug products, establishing robust, scalable workflows and ensuring regulatory compliance across NATi's translational programs.
ResearchOnsite
Key Responsibilities
- Develop and execute a phase‑appropriate analytical characterization strategy for raw materials, drug substances, and drug products
- Select and implement analytical workflows using orthogonal techniques such as HPLC, LC‑MS, CE, UV spectroscopy, qPCR, DLS, and TEM
- Apply Quality by Design principles to define critical quality attributes and ensure method robustness and scalability
- Collaborate with cross‑functional project teams to align analytical strategies with product development goals
- Develop and maintain SOPs, method validation plans, and analytical documentation in compliance with industry standards and regulatory expectations
- Maintain accurate records using LIMS/ELN systems to support data integrity and reproducibility
Requirements
- Doctorate degree in Analytical Chemistry, Pharmaceutical Sciences, or a related field
- Minimum 4 years (Scientist) or 8 years (Senior Scientist) hands‑on experience in analytical development for nucleic acid therapeutics
- Hands‑on experience with multiscale purification methods (e.g., preparative RP‑HPLC, affinity, ion‑exchange