About the role
Lead Research Officer in Translational Neuroscience at A*STAR IHDP, focusing on gene and environmental research influencing child outcomes, developing neurobiological battery, and applying bioinformatics to genetics data.
ResearchOnsite
Key Responsibilities
- Develop and apply appropriate approaches for quantifying and correcting for biases in genomics data
- Advancing bioinformatics and statistical analyses related to genetics and environmental influences on child outcomes, including genome-wide association studies (GWAS), whole-genome sequencing (WGS) analysis, fine-mapping, and rare variant analysis, and polygenic risk score (PRS) creation
- Developing and validating risk prediction models, specifically utilizing PRS to tailor disease screening and prevention strategies, often in a clinical or primary care setting.
- Scripting and automating robust analysis pipelines to query, retrieve and analyse information in the dataset
- Working within interdisciplinary teams of researchers and presenting work in progress, preparing reports, and contributing to manuscripts for peer-reviewed publications and grant application
Requirements
- PhD degree in bioinformatics, statistical genetics, human genetics, computer science or related field, or Master in related fields with relevant experience in genetics or other complex biological.
- Track record of experience and training in biological data, data analyses and data mining on genomic datasets.
- Demonstrate strong understanding of bioinformatics approaches such as genetic associations, polygenic risk scores.
- Strong programming skills in Unix and at least R and/or Python.
- Proficient with statistical analysis and experience in advanced computational methods (e.g., machine learning) would be advantageous.
- Excellent written, communication and organizational skills, with experience working independently and in multi-disciplinary teams.